Life needs time.
After implantation, embryo is recognized by the mother like an external agent activating the inflammation process by producing pro-inflammatory cytokines. At the same time embryo produces anti-inflammatory signals for the mother for silencing inflammations so that healthy pregnancy is a perfect balance between pro-/anti-inflammatory species.
In the last phase of a physiological pregnancy, inflammation increase as process for inducing the delivery.
High and persistent premature inflammation during healthy pregnancy lead to elevated risks of pre-term delivery and miscarriage.
Gestational Diabetes Mellitus is worldwide public health problem defined as glucose intolerance that begins or is first recognized during pregnancy and it is associated with fetal, newborn and maternal risks. The prevalence of GDM is rising together with the increasing prevalence of type 2 diabetes and obesity around the world and in most of cases it is part of a complicated dysmetabolic condition.
Current therapeutic options don’t cover prevention GDM onset and treatment of borderline conditions.
Except for bleeding-induced anemia, main cause of iron deficiency is due to intestinal absorptions alterations.
This is why only 10% of iron from diet is absorbed while the major problem with oral iron therapy is poor tolerability and gastrointestinal side effects such as nausea, vomitus, diarrhea and abdominal pain as consequence of its gastric dispersion and less absorption.