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Infertility is defined as “a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse”

15% of all couples over the world is infertile, while male infertility is responsible for 30% of cases.

Except for specific diseases, semen alterations (Oligo-astheno-teratospermia) are the main cause of male reduced fertility.

Anyhow an important rate of male with fertility problems cannot find an answer to clarify the origin of these problems.